The virus that caused the Covid-19 pandemic was most likely created in a laboratory, a study by German and American scientists has claimsed. A team of three researchers concluded that Sars-CoV-2 was a genetically modified virus, after comparing its structure to that of “wild” and laboratory-borne equivalents.
Sars-CoV-2 literally has “fingerprints” of genetic manipulations, according to a preprint released by Valentin Bruttel of Germany’s Wuerzburg University, Alex Washburne of the US-based Selva Analytics research center and Antonius VanDongen of Duke University, also in the US. The paper published this week reported that the three scientists had found a recurring genetic structure element called a restriction site, which they describe as a sign of the virus’ genome having been “stitched” together.
“To make a virus in the lab, researchers usually engineer the viral genome to add and remove stitching sites, called restriction sites. The ways researchers modify these sites can serve as fingerprints of in vitro genome assembly,” the paper, which has not yet been peer-reviewed, claims. The structure of Sars-CoV-2 is “anomalous in wild coronaviruses” but “common in lab-assembled viruses,” it adds, pointing to the certain “synonymous or silent mutations” that differentiate the restriction sites. The concentration of such mutations “is extremely unlikely to have arisen by random evolution,” the preprint says.