Effective vaccines are essential to stop the novel coronavirus diseases 2019 (COVID-19) pandemic, and administration of over 4 billion vaccine doses since December 2020 is an unprecedented effort.1 Large-scale vaccination resulted in the discovery of rarer side effects that were previously not reported during clinical trials.
We present 2 cases of drug-induced liver injury (DILI) without features of autoimmune hepatitis after administration of the Pfizer BioNTech COVID-19 mRNA vaccine. A 38-year-old woman with asthma and no prior history of liver disease or allergies received her first dose of the Pfizer BioNTech COVID-19 mRNA vaccine on March 4, 2021.
Six days after vaccination, she noted jaundice, tea-colored urine, and generalized itchiness. She denied consumption of alcohol, drugs, over-the-counter medications, or herbal supplements.